The games continue to come thick and fast in a crammed schedule for the 2020-21 season.
Jose Mourinho returns to former club Manchester United with Tottenham in one of the highlights of the Premier League weekend, while champions Liverpool visit in-form Aston Villa.
Everton and Leicester City aim to build on fine starts at home to Brighton and Hove Albion and West Ham, while Chelsea and Arsenal welcome Crystal Palace and Sheffield United respectively.
It promises to be another incident-packed weekend in the Premier League, so before getting comfy on your sofas, why not have a crack at our Opta-powered quiz?
1. Crystal Palace are looking to win their opening two away matches of a Premier League season for the third time (also 1997-98 and 2015-16) and could become only the second team to win at Stamford Bridge and Old Trafford in consecutive away Premier League games. Who were the first to do so?
2. This will be Everton boss Carlo Ancelotti s 100th Premier League game as a manager (W59 D19 L21). Only five coaches have won more of their first 100 in the competition than the Italian. Who are they?
3. Leeds United s Pablo Hernandez scored three league goals against Pep Guardiola s Barcelona for Valencia between 2009 and 2011. Only two players have scored more top-flight goals against teams managed by Guardiola, one is Diego Forlan (4) – who is the other?
Whilst Pablo is out, Helder is keeping up our megs quota
— Leeds United (@LUFC)
4. London sides have not won any of their previous eight Premier League visits to Leicester City (D2 L6). West Ham aim to end that run this weekend, but which capital team was the last to beat the Foxes away in the competition?
5. Arsenal face Sheffield United this weekend. The Gunners are currently on the longest ever Premier League streak of avoiding defeat at home against sides starting the day in the relegation zone. How long is that run?
Answers:
1. Sunderland (April/May 2014)
2. Jose Mourinho (73), Pep Guardiola (73), Manuel Pellegrini (65), Alex Ferguson (62) and Roberto Mancini (62)
3. Jamie Vardy (8)
4. Crystal Palace (4-1 in February 2019)
5. 40 (dating back to a 1-0 defeat against West Ham in April 2007)